Image interpretation relies heavily on human perception and decision-making. Failure rates and false alarms are high, due to the disruptive environment and other external variables such as the pressure to perform or tiredness. Majority of the scanned bags do not contain threats, which can result in complacency as time passes. While many actual threats are missed because of image complexity and the difficulty posed by the object’s viewing angle, the list of prohibited items continues to grow, challenging the human operator even more.